In my research, I've found that combining Simvastatin, a popular cholesterol-lowering drug, with grapefruit can be a risky mix. Grapefruit contains compounds that interfere with the enzymes that break down the medication in your body, leading to higher levels of the drug in your bloodstream. This can increase the risk of side effects, including muscle damage. Therefore, experts often warn against consuming grapefruit when taking Simvastatin. It's always best to consult with your doctor about potential food-drug interactions.